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Specific inhibitors for aromatase, such as anastrozole , have been developed for use in the treatment of estrogen-dependent tumors ( see Chapters 40 and 6063)

Despite mechanistic interest and some preliminary signals, clinical trials in AD have not provided evidence of therapeutic benefit from lithium, and its toxicity profile limits its practical use in patients

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384 Moreover, the involvement of CaSR in vascular remodeling is further supported by its interaction with PDGF signaling, where PDGF upregulates CaSR expression in PASMCs, driving excessive proliferation and vascular remodeling in IPAH