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Arsenault, Benoit J., et al

Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

Morris, M

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The most commonly observed finding on MRI in patients with PNPO gene mutations is cerebral atrophy, followed by basal ganglia ischemia, cerebral myelin dysplasia, cortical laminar necrosis and cortical edema