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ACS Central Science

10.1016/S0002-9394(01)01365-4

Epub 2021 Apr 20 Mainprize T, Lipsman N, Huang Y, Meng Y, Bethune A, Ironside S, Heyn C, Alkins R, Trudeau M, Sahgal A, Perry J, Hynynen K (2019) Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound: a clinical safety and feasibility study

The most important challenge is to overcome melanoma resistance, due to melanosomal trapping, the presence of melanin, enhanced oxidative stress defense, defects in the apoptotic pathways, immune evasion, and neo-angiogenesis stimulation [180]