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In animal models, these systems have demonstrated pain relief through multiple mechanisms, including modulation of cell death pathways, suppression of neuronal hyperexcitability, and anti-inflammatory and antioxidant effects

This pro-ferroptotic pressure is countered by selenoprotein-dependent antioxidant defenses by selenoenzyme GPX4 [49]

Doyle TM, Salvemini D

Adult conditional knockout of PGC-1 leads to loss of dopamine neurons

[PUBMED Abstract] Hrusak O, de Haas V, Stancikova J, et al.: International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia

Iron metabolism disorder is an important factor in inducing ferroptosis