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Thalassemia: Thalassemia carriers are asymptomatic or mildly symptomatic and do not require treatment

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Similarly, trastuzumab, a monoclonal antibody that binds HER2, is used to treat HER2-positive breast cancer but resistance is problematic [50] and in vitro studies with SKBR3 breast cancer cells implicate activated IGF-1R in this process [51], which is reversed by inhibition of IGF-1R [52]