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Prior studies have used the cell cycle proteins p16, p21, p53 and Rb to differentiate between dividing and non-dividing cells, but the non-dividing cells can include senescent cells and quiescent cells 36

Parental MCF-7 were cultured in growth medium containing 5% fetal bovine serum (FBS) with increasing amount of Tamoxifen, starting from 0.5 M initially, finally up to 5 M in a period of around 6 months

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doi: 10.1038/s41598-018-27580-1 90

Advances in Targeting the Folate Receptor in the Treatment/Imaging of Cancers Fernandez, M., Javaid, F., Chudasama, V.* Chem Sci , 2018, 9, 790-810

The role of cancer-associated fibroblasts in cancer invasion and metastasis