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Important Safety Information Contraindications and Precautions: Joint injections should only be performed by qualified medical professionals Active joint infection is an absolute contraindication to intra-articular injection Bleeding disorders or anticoagulation therapy may increase injection risks Pregnancy and breastfeeding: no safety data available, avoid use Cancer history: while AOD-9604 does not affect IGF-1, consult oncologist before use Monitoring Recommendations: Regular follow-up with joint imaging and functional assessments to evaluate treatment response

Dosing & Reconstitution Guide Subcutaneous, once or twice daily Subcutaneous Protocol (2 mL = 5 mg/mL) Frequency: Inject once or twice daily subcutaneously

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The average values of maximum plasma concentration, elimination half-life, plasma clearance and volume of distribution after a 50 mg/kg IV dose and after a 75 mg/kg IV dose in pediatric patients suffering from bacterial meningitis are shown in Table 3

The capsules can be opened for analytical or assay work that requires the dry powder