l-carnitine cas number Acetyl-L-Carnitine highlighting its role in energy metabolism and muscle recovery (Fielding et al. C2) Acetylcarnitine | CAS#:14992-62-2 (inner

8 Advantages and realistic prospects of drug repurposing in AD As already mentioned in section 6, drug repurposing represents the strategic identification of new therapeutic uses for existing approved or investigational drugs (Recino et al., 2025)

Missense Common mutation: Glu474Gln Reduces LCHAD activity Homozygous clinical: Neonatal death Allelic disorders Trifunctional Protein Nosology: Trifunctional protein, subunit Functions Catalyzes steps in long-chain intra-mitochondrial -oxidation Source of energy: Skeletal muscle & Heart MTP deficiency also caused by mutations in: HADHB MTP components Heterooctameric HADHA (LCHAD & LCEH enzymes) HADHB (LCKAT enzyme) Location: Inner mitochondrial membrane Common defect in MTP: LCHAD See: Lipid disorders Clinical: Several syndromes HADHA variant: Infant syndrome Clinical Onset: 1st 2 years Cardiomyopathy Muscle: Hypotonia Hepatomegaly Retinopathy: Pigmentary Course Recurrent metabolic crises, or Steadily progressive Death Arms

Insulin appears to assist muscle carnitine uptake, which is why several trials paired the dose with carbohydrate

Neo-B12 Injection supplements deficient levels of vitamin B12, which allows red blood cells to develop and produce normal levels of haemoglobin, relieving symptoms of anaemia

Limitations Although we identified DMGs as a result of variations in the timing of hypoxic stress, our results may be confounded by the use of whole-body tissue samples

TTE, time-to-exhaustion