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Although this remains to be confirmed, one possibility is that Ator1, adjacent to the pore-forming domain, binds with the highest affinity, as it requires only minimal conformational changes in RyR1 to allow its binding

10.1016/j.plaphy.2011.10.020 81 KogovsekP.Pompe-NovakM.BaeblerS.RotterA.GowL.GrudenK.et al

"That is an active form in the body, but your body will have no trouble converting cyanocobalamin." If the latter is more reasonably priced, there's no need to spend more on the former