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In addition, it has been found that inflammation can induce GERD by decreasing the function of the upper laryngeal-esophageal sphincter and pharyngeal-esophageal sphincter receptors (67)

Accordingly, glutamine metabolism plays a role in gene expression through the contribution of -ketoglutarate and succinate to chromatin structure modification

Front Immunol 16:1702860 Gokay G, Goncu B, Atasoy S, Kandas NO, Dag A (2022) Sulforaphane, a chemopreventive compound induces necrotic behavior and inhibits S-phase of cell cycle in human kidney cells in vitro

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Li Y, Wu T, Wang Y, Yang L, Hu C, Chen L, et al

Caffeine can be absorbed through the rectum, similar to drinking a cup