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Besides the increase of this oxysterol, which acts as a precursor of CDCA, the primary BA synthesized in the mitochondrial alternative pathway, STARD1-mediated cholesterol trafficking results in accumulation of cholesterol in the MIM, which results in far-reaching consequences, such as disruption of mitochondrial physical properties, leading to decreased membrane fluidity that impairs mitochondrial antioxidant defense, illustrated by the depletion of mitochondrial glutathione (GSH) [131135]

We performed a paired t -test (Wilcoxon signed-rank sum test) for two variables (tetranor-PGDM and tetranor-PGEM concentrations) in the same group

311337 Sung YY, MacRae TH, Sorgeloos P, Bossier P (2011) Stress response for disease control in aquaculture