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RdRP activity can be detected in extracts from replicon-bearing cells, although this seems to reflect elongation of co-extracted templates rather than de novo initiation

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For instance, the reader of m 6 A, insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), undergoes lactylation at K76, promoting the m 6 A modification of phosphoenolpyruvate carboxykinase 2 (PCK2) and nuclear factor erythroid 2-related factor 2 ( NRF2 ) mRNAs, which reprogram serine metabolism in HCC cells

doi: 10.1038/bjc.2011.585

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

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