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Additionally, Fructus Aurantii flavanones extracts decreased the F:B ratio, increased the relative abundance of the genera Akkermansia and Alistipes , and decreased the relative abundance of the genera Dubosiella , Faecalibaculum and Lactobacillus (Reference Bai, Wang and Wang75)

Based on the calcium dependence of calcineurin (CaN), calcium further serves as a second messenger to drive the CaN/nuclear factor of activated T cells (NFAT) pathway, participating in osteoblast proliferation, differentiation, and apoptosis (96)