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The most compelling mechanism is its proven ability to induce angiogenesisthe formation of new blood vessels

PMID: 39030423 Nat Cell Biol Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression

The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction

1-palmitoyl-2-(5-oxo-valeroyl)-sn-glycero-3-phosphocholine), heavily toxic OxPCs that trigger ferroptosis, accumulated in sulfasalazine-treated kidneys after IRI