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The animals fed a selenium-deficient diet recapitulated some of the pathological manifestations of KBD, strongly supporting the notion that selenium deficiency is critically associated with the development of this endemic arthropathy

Regularly, astrocytes are the main source of NO, however, it has been shown that NT2 neurons can produce NO and therefore increase levels of cGMP (Denninger and Marletta, 1999)

Zinc plays a vital role in maintaining the homeostasis of intestinal epithelial cells, and its deficiency can lead to alterations in their integrity and function

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Cadmium (Cd) is a common heavy metal contaminant that has been demonstrated to cause organ damage through the activation of inflammatory processes, oxidative stress, mitochondrial damage, and cell death, which ultimately leads to neurotoxicity, gastrointestinal damage, renal damage, and reproductive damage [124, 125]

SOD1 and SOD2 convert intracellular superoxide to H 2 O 2 and oxygen molecules, while SOD3 converts extracellular superoxide to H 2 O 2 and oxygen molecules