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Mitochondria are the powerhouse of the cell, continuously providing large amounts of adenosine triphosphate (ATP) to cardiomyocytes which require an extraordinary ATP turnover to maintain contractile function

Supportive secondary endpoint analyses were not controlled for multiple comparisons and should not be used to infer definitive treatment effects

Morphine has latent deleterious effects on the ventilatory responses to a hypoxic challenge

doi: 10.1002/2211-5463.12103

L-glutamate is also the precursor of glutathione (L--glutamyl-L-cysteinylglycine, GSH)

The resulting accumulation of superoxide radicals further exacerbates oxidative stress, forming a vicious cycle that accelerates the progression of DR