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Glycocalyx function Regulating vascular permeability Notably, glycocalyx degradation exacerbates vascular permeability by disrupting VE-cadherin and occludin [41], while intact glycocalyx suppresses MMP-9-mediated inflammation [42, 43]

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Contractility Single-myocyte contractility was inhibited in the myocytes isolated from iron-overloaded hearts (Figure 5A)