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A recent meta-analysis of 21 randomized controlled trials on the effect of folic acid supplementation on endothelial function suggests that this intervention significantly improves flow-mediated dilation percentage (FMD%) and flow-mediated dilation, but not end-diastolic diameter (EDD) or intracellular adhesion molecule 1 (ICAM-1) expression (Zamani et al., 2023)

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Non sono stati effettuati adeguati studi clinici in donne in gravidanza

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The generation of ROS is further exacerbated under conditions of elevated mitochondrial membrane potential (m) or an imbalanced NADH/NAD+ ratio