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Moreover, alteration of the administration order of Bu-Cy to Cy-Bu gives the same engraftment outcome but reduces the toxicity of the conditioning regimen both in patients and mice 59,60

3.2 Bidirectional regulation of lipid metabolism Lipid metabolism serves as a critical bidirectional regulator of CD4 + T cell differentiation, dynamically shaping the balance between pro-inflammatory Th17 cells and immunoregulatory Treg cells through integrated control of extracellular lipid uptake, intracellular synthesis, and FAO (90, 91)

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5 , CD001287 (2019)

Research protocols sometimes combine matrikine signals with broader gene modulators to address both the targeted collagen induction pathway and the broader tissue remodeling network simultaneously