glutathione reduces toxicity of epoxides The Key Role GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates GPX4 in cell death, autophagy,

Protects Skin from Aging and UV Damage Ergothioneine builds up in skin cells through the OCTN-1 transporter and helps counter several key drivers of skin aging: Sun damage: Absorbs UV light and helps prevent UV-triggered DNA damage [14] Collagen loss: Inhibits MMP-1, the enzyme that breaks down collagen [15] Uneven tone: Clinical data show reduced wrinkles, age spots, and hyperpigmentation by suppressing excess melanin [15] Loss of firmness: Protects collagen and elastin and supports better hydration and elasticity [15] Inflammation: Its anti-inflammatory properties help calm acne, rosacea, psoriasis, and atopic dermatitis, and in some models it outperforms coenzyme Q10 and vitamin C against free radicals [15] These benefits have been observed with both topical ergothioneine and oral supplementation

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Identification of an acetoacetyl coenzyme A synthetase-dependent pathway for utilization of L-(+)-3-hydroxybutyrate in Sinorhizobium meliloti

doi: 10.1016/j.jncc.2025.01.007 Summary Keywords colorectal cancer, microsatellite stable, antibody-drug conjugate, immunoconjugate, immuno-oncology Citation Wang Y, Lu K, Xu Y, Xu S, Chu H and Fang X (2025) Antibody-drug conjugates as immuno-oncology agents in colorectal cancer: targets, payloads, and therapeutic synergies