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Elevated NNMT expression has been observed in adipose tissue of animals with insulin resistance, and modulation of this enzyme has been shown to influence weight and metabolic function in preclinical models

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10 mg/mL Usual Adult Dose for: Additional dosage information: Usual Adult Dose for Non-Small Cell Lung Cancer 500 mg/m2 IV on Day 1 of each 21-day cycle Comments: Limitations of Use: This drug is not indicated for the treatment of patients with squamous cell non-small cell lung cancer (NSCLC) With pembrolizumab and platinum chemotherapy for the initial treatment of metastatic nonsquamous NSCLC: This drug should be administered after pembrolizumab and before carboplatin or cisplatin on Day 1 of each 21-day cycle for 4 cycles