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Emodin protects hepatocytes against APAP-induced injury by upregulating the nuclear factor erythroid2-related factor 2 (NRF2)-mediated antioxidant stress pathway, inhibiting NLRP3 and downregulating the cGAS-STING signaling pathway [239]

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The melatonin rhythm has the primary function of influencing the circadian clock at the level of the suprachiasmatic nucleus (the CSF melatonin) and the clockwork in all peripheral organs (the blood melatonin) via receptor-mediated actions