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It impairs insulin signaling and hepatic glucose metabolism, affecting glycogen synthesis and gluconeogenesis (Kalagi et al., 2022) (Figure 4)

The shared decision-making process must still consider patient and caregiver preferences

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Previous studies suggest that nearly 50% of NAFLD-related HCC cases likely arise from patients with underlying NASH rather than from those with simple steatosis (NAFL) [17]

doi: 10.1016/j.cels.2015.08.012 196 OuyangY

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