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Overmethylation, a condition characterized by an excessive addition of methyl groups to DNA, RNA, proteins, and neurotransmitters, can result from a complex interplay of genetic, environmental, and dietary factors

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway

However, TMZ sensitivity is significantly affected by the level of O 6 -methylguanine-DNA methyltransferase, which can remove TMZ-induced alkylation from nucleotides and has been employed as a predictor of responsiveness to alkylating drugs (Tomar et al

Weber, L., Kuck, K., Jrgenliemk, G., Heilmann, J., Lipowicz, B., & Vissiennon, C

10.1089/zeb.2021.0083 59 ClassonD.WangT.MalteH

Diamond LW, Nguyen DT, Andreeff M , Maiese RL, Braylan RC