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No antiviral agents to manage DENV infections are yet licensed and the clinical benefit of the available tetravalent DENV vaccines, Dengvaxia and Qdenga, are limited by safety concerns and inconsistent long-term efficacy across the four DENV serotypes (Sridhar et al., 2018)

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As a result, cell death in IBD may activate other cell death processes, and in the presence of an inflammatory environment, the vicious cycle of cell death persists