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Ollivier, M

Therefore, the use of KD in individuals with PD can raise concerns, as their nutritional status is a significant factor affecting lifespan, and people with PD are already at a high risk of malnutrition

153 Thus, whether these observations constitute examples of bona fide on-target resistance or rather reflect the critical role of mitochondria (and in particular of the PTPC) in CDDP-elicited cell death, hence constituting examples of post-target resistance, remains an open conundrum

Additional amounts are added to ensure effectiveness over time

Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig

Aquat Toxicol 80:249260 Jamers A, Blust R, De Coen W (2009) Omics in algae: paving the way for a systems biological understanding of algal stress phenomena