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For comparison, we treated cells with tunicamycin (TUN, a widely-used ER stress inducer) which did not alter phospho-GCN2 (T899), but reduced the mobility of PERK, indicative of its increased phosphorylation (Fig

Extracellular glutamine is taken up into neurons by SAT1,2 (Kanamori and Ross, Although not shown in Figure 3B (for the sake of simplicity), the subsequent de-amidation of glutamine to glutamate appears to be somewhat complex, probably reflecting the subcellular localization of the phosphate-activated glutaminase (PAG)

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The author is grateful for Ming Li, Cizhong Jiang and Liyong Wangs discussions

Fumaric Acid Esters Exert Neuroprotective Effects in Neuroinflammation via Activation of the Nrf2 Antioxidant Pathway

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