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, and lower affinity for the flavin cofactor than the C/C form of the enzyme

Considering that the TNF--induced H 2 O 2 burst has been previously shown to cause oxidative inactivation of JNK phosphatases 54 , JNK hyperactivation is a result of the dual action of GPx1 in regulating H 2 O 2 , which leads to activated ASK1 and inactivated JNK phosphatase

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Glutathione (GSH) is essential for various bodily functions, particularly in maintaining cell health by regulating the balance between antioxidants and oxidants

EGCG interacts stronger with amyloidogenic mutants To gain insights into the mode of action of EGCG, we quantified the kinetics of EGCG-induced precipitation using solution-state NMR