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All animal experiments were approved by and conducted in compliance with Institutional Animal Care and Use Committee (IACUC) of the University of Colorado Anschutz Medical Campus

As a result, numerous researchers have dedicated themselves to investigating the mechanism of platinum drugs to prevent or lessen their toxic effects.Studies indicate that numerous chemical drugs and herbs possess the capability to hinder oxidative stress caused by cisplatin by eradicating free radicals and increasing the activity of antioxidant enzymes, ultimately providing reproductive and genotoxic protection against cisplatin

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Because of a lack of strong evidence, obstetricians recommend avoiding extra glutathione until after delivery for safety

Most of the differentially regulated pathways in contrasts 1 and 2 (MOD vs