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In the co-culture system, MCECs derived from the model group exhibited significant reduced ZO-1 and Occludin expression compared to those from the Control group, whereas GHK-Cu elevated theses protein levels (Figures 4GI)

The metabolomics data generated in this study are available at the NIH Common Funds National Metabolomics Data Repository, Metabolomics Workbench, under project ID PR003037 and can be accessed at the Metabolomics Workbench ( The results of the in vitro and in vivo metabolome screens reported here are publicly available through an interactive resource ( Publicly available infant microbiome datasets analysed in this study are available from NCBI Sequence Read Archive (SRA) under accession numbers PRJNA633576, PRJNA740120, PRJNA833324 and PRJNA390646

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