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Oncology Update, 1990

During oxidative stress, ROS directly interact with amino acid side chains (mainly lysine, arginine, proline, and threonine), or peptide bonds in the polypeptide chain are broken and carbonyl groups are formed inside the polypeptide structure (168)

VRK2 knockdown also led to reduced binding of Sec24C and SLC7A11 (Fig

Causes of death included BT (37%), cardiovascular disease (18%), progressive disease with multiorgan failure (16%), sepsis or other non-respiratory tract infections (13%), pneumonia or other respiratory tract infections (9%), and other (8%), including non-myeloid cancer deaths in 6 patients

Surgical resection is the sole potentially curative option for CCA (Blechacz, 2017), but a study of patients with iCCA in the US National Cancer Database found only 21.9% underwent surgical resection (Wu et al., 2019)

4.0 4.1 4.2 Liu Y, Lu D, Zhang Y, Li S, Liu X, Lin H (September 2010)