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The chronic inflammatory milieu created by these mechanisms accelerates degenerative changes in organs such as the brain, vasculature, joints, and adipose tissue

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LEAP2 as a therapeutic target in obesity and cardiometabolic disorders

This pattern promising small trials followed by null large trials is one of the most common failure modes in pharmaceutical development

Monitoring response to treatment involves: Clinical assessment of symptom improvement, including mouth ulcer frequency FBC to confirm resolution of anaemia and reticulocyte response Ongoing monitoring of neurological symptoms if present Routine repeat measurement of serum B12 levels shortly after starting injections is not generally recommended as results may be misleadingly high