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Folic acid supplementation can alleviate the symptoms of anemia in patients with dihydrofolate reductase deficiency, but this does not correct the deficiency of tetrahydrofolate in the brain, often leaving neurological sequelae

& Choe, Y

A colonoscopy is contraindicated in most cases, and doctors may utilize abdominal X-rays instead to see the progression of the disease

: Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitution

HSP70 interactome HSP40/DNAJ Molecular chaperones such as HSP40s, or DNAJs, assist HSP70s in their foldase activity (Venediktov et al., 2023) (Figure 4)

Cell 169, 301313