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demonstrated that KHK-C promotes fructose metabolism, leading to energy imbalance and increased oxidative stress, which in turn drives tumor cell proliferation and survival

Toxicol in Vitro 39:5257

Ghoshal et al 266 reported that global genetic deficiency of COX-2 in mice resulted in a significant reduction in total body weight and body fat by attenuating PPAR ligand production and adipocyte differentiation