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For comparison, FDA-approved anti-obesity medications like semaglutide 2.4 mg (Wegovy) have cardiovascular outcomes data from the SELECT trial (N=17,604, median follow-up 39.8 months), which demonstrated a 20% reduction in major adverse cardiovascular events [6]

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Since the intestinal microbiota takes approximately 2.5 years to become functionally mature, the clinical impact of any large shifts in microbial composition during this developmental period can significantly impact intestinal permeability [57]