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There are various causes for IP, such as drugs, collagen disease, viral infection, and radiation therapy 1

For instance, glutathione peroxidase activity was considerably lower in those with insomnia, according to a study that compared the levels of glutathione in 30 healthy individuals with 30 individuals with insomnia

Thats a significant toxic load hitting your endocrine system at its most vulnerable

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Animals were monitored over the course of experimentation and confirmed that animals were awake and alert following anesthesia

PMID 7811344