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Front Med , 7

1 Introduction Cancer is a global health concern, with an estimated 19.3 million new cases and almost 10 million deaths reported in 2020 (Sung et al., 2021)

10.1126/scisignal.aas8779 16 GulerG

doi: 10.1016/j.jsbmb.2015.09.029 64 YueLYihuaiHYawenL

The consequential cellular transformations and protein responses resulting from these interactions play a significant role in shaping the tumor micro-environment