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However, this may reflect the existence of PDE as various isoenzymes (at least 11 members to this superfamily, each located in different sites within the cell, some of which are inaccessible to drugs)

Cell Stem Cell 26 , 391402 (2020)

Proteomics 118 , 95111 (2015)

Biochemical analysis of mouse serum Serum insulin levels were measured in a 96-well microplate using a commercial Morinaga Ultra Sensitive Mouse/Rat Insulin ELISA Kit (MIoBS, Japan)

Glossary ACC1 Acetyl-CoA carboxylase 1 ALD Alcoholic liver disease ALP Alkaline phosphatase ALT Alanine aminotransferase AMPK AMP-activated protein kinase AST Aspartate aminotransferase CARM1 Coactivator-associated arginine methyltransferase 1 DIC Diclofenac DILI Drug-Induced Liver Injury EGCG epigallocatechin-3-gallate EGFR Epidermal growth factor receptor EMT Epithelial-mesenchymal FATP 2 fatty acid transport protein 2 FFA Frontal fibrosing alopecia GA Gallic acid -GT Gamma-glutamyl transferase HA Hyaluronic acid HCC Hepatocellular carcinoma HFD High-fat diet IL-1 Interleukin 1 IL-6 Interleukin 6 LNCs Lipid nanocapsules LXR- Liver X receptor-alpha MDA Malondialdehyde MMP-2 Matrix metalloproteinases-2 NAFLD Non-alcoholic fatty liver disease NF-B Nuclear factor kappa B Nrf2 Nuclear factor erythroid 2-related factor 4-OMeGA 4-O-methyl gallic acid PELP1 Proline, glutamate, and leucine-rich protein 1 PGG Penta-o-galloyl--D-glucose PI3K Phosphoinositol-3 kinase PON1 Paraoxonase1 PPAR- Peroxisome proliferator-activated receptor alpha RMLNC Reverse micellar-loaded lipid nanocapsules SA Sodium nitrite SREBP-1c Sterol regulatory element-binding protein-1c TAA Thioacetamide TG Triglyceride TGF- Transforming growth factor-beta TIMP-1 Tissue inhibitor of matrix metalloproteinases-1 TNF Tumor necrosis factor alpha References 1 AbenavoliL.LarussaT.CoreaA.ProcopioA

Furthermore, other structural biology techniques suggested the existence of IDPs and IDRs before they were actually described by NMR and X-ray crystallography