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Consequently, the bioavailability concept encompasses two fundamental aspects: bioaccessibility and subsequent biological activity 21,22 (Fig

Addressing these gaps requires multi-dimensional studies integrating single-cell omics, spatial transcriptomics, and clinical cohort analyses to resolve pathway crosstalk, define cell type-specific roles, and bridge preclinical and clinical translation, ultimately advancing ferroptosis-targeted strategies from bench to bedside in AKI treatment