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Targeting these features simultaneously holds the potential to achieve true disease modification, as it addresses the complexity and multifactorial nature of neurodegeneration

Unsupervised hierarchical cluster analysis and supervised orthogonal partial least squares discriminant analysis (OPLS-DA) were performed using the Metaboanalyst 5.0 web server 45 (accessed on August 2022) Variable Importance in Projection (VIP) scores greater than 1 was considered to select relevant variables in the models 46

Surgical removal of the lesions is the first-line intervention

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Polymorphic site substitutions present in 2 participants in the study were observed in 10, 6, 18, 8 and 6 participants at Weeks 192, 240, 288, 336 and 384, respectively