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Publicerad 23 december 2025

The gap between molecular data and clinical outcomes remains significant

Apelin-13 promotes neuroprotection and anxiolytic effects through increased SIRT1 acetylated p65 (lysine 310) in CNH-treated mice [222]

10.1016/j.cell.2007.06.009 Cell 42 ManningB

These effects were contributed to benfotiamine's action on transcription factors NF-B and Egr-1, arachidonic acid pathway, protein kinase C and members of MAPK signaling cascade p38, ERK1/2, SAPK/JNK [14,15]