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A MAPP Network study: overexpression of tumor necrosis factor- in mouse urothelium mimics interstitial cystitis

Possible causes include bacterial infections, parasitic infections (worms or single-celled parasites), or an allergy or intolerance to a specific protein in the diet

Neurology 72 , 439446 (2009)

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For the last fifty years, it has commonly been used in sterilizing the GI tract, permanently reducing the population of many beneficial bacteria species