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FEBS Lett 1991

Sern, AnnaKaisa Tuomaala, Johan Jendle, Pratik Choudhary, Emanuele Bosi, Viswanathan Mohan, Tim van den Heuvel, Ohad Cohen, Richard F

To better clarify the relevance of cysteine and other thiols in ovarian cancer, we analysed their levels in peripheral blood serum from patients with benign and malignant tumours, from healthy individuals and in ascitic fluid from ovarian cancer patients

All these results allowed to conclude that APR-246 induces early cell death by ferroptosis, a recently described non-apoptotic form of regulated cell death that links together membrane lipid peroxidation, cysteine and iron metabolism, glutathione peroxidase activity and oxidative stress (as summarized in Figure 4A 2325 )

Creatine monohydrate is non-enzymatically converted to creatinine in skeletal muscle, and supplementation at standard 3 to 5 g per day doses reliably elevates serum creatinine 1

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