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Some men use TRT long-term because they feel significantly better and the benefits justify the commitment

Garcia-Fernandez M, Sierra I, Puche JE et al (2011) Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats

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lower, optimal-dose anti-angiogenic treatment could be more advantageous than higher-dose therapy to establish a favorable TME leading to the therapeutic benefit

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