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Biol Chem 401(11):12571271

In addition, energy stores (ATP) become depleted, whereas the expression of proinflammatory cytokines, adhesion molecules, and bioactive agents such as endothelin and thromboxane A 2 become accelerated [59,60]

Concurrently, the emergence of molecularly intelligent photosensitizers that change their photophysical or chemical behavior in response to lesion-specific cues (pH, enzymes, redox) exemplifies how analyte-sensing functionality can be built directly into imaging-therapeutic agents

NAD+ is also essential for PARPs (poly-ADP-ribose polymerases), another family of enzymes crucial for DNA repair and genome stability