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Similarly, heavy metals such as cadmium, lead, and mercury, often encountered in industrial settings or contaminated water and food supplies, interfere with mitochondrial function and catalyze the production of free radicals [7, 8]

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10.1104/pp.104.045625 Plant Physiol

Vazeille E, Codran A, Claustre A, Averous J, Listrat A, Bechet D, Taillandier D, Dardevet D, Attaix D, Combaret L (2008) The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy

#4 Environmental Toxins Exposure to environmental pollutants, heavy metals (such as lead, mercury, and arsenic), pesticides, and other toxins found in air, water, and food sources can impair glutathione synthesis and utilization