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demonstrated that sodium dichloroacetate, a metabolically targeted agent, improved cardiac function in HF patients by optimizing substrate utilization, underscoring the translational potential of metabolic ( Critical unresolved scientific questions include elucidating the mechanistic role of metabolic reprogramming across disease stages ( 3.2 Atherosclerosis Atherosclerosis, a disease characterized by chronic vascular inflammation and lipid deposition, drives the development of cardiovascular, cerebrovascular, and peripheral vascular pathologies through plaque formation

2 By the time of 1988, researchers had realized that TGF- generally remained non-covalently associated with the N-terminal segment of its precursor when it was secreted

References Ashley, E

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