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It indicates that activation of HDAC4 promotes neuronal excitotoxicity, a hallmark of epilepsy

Front Physiol 2015

Nakajima K, Tohyama Y, Kohsaka S, Kurihara T (2002) Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro

When OH is produced, it reacts with macromolecules in its proximity resulting in lipid peroxidation as well as oxidation of proteins and nucleic acids