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Kim 16 , Andres Duarte-Rojo 17 , Omobonike Oloruntoba 18 , Amit D

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No control group

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Kangen machines work through electrolysis passing an electrical current through water to separate it into alkaline and acidic streams

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N Engl J Med 2020;382:150719

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2.6 P53 The p53 protein serves a critical role in the cellular response to iron overload, maintaining a balanced state of iron by finely regulating the transcriptional activity of specific genes ( Moreover, p53 is not only involved in iron homeostasis regulation but also enhances the cellular antioxidant defense system by activating the expression of a series of antioxidant enzymes, including GSTs, HO-1, and superoxide dismutase (SOD) ( When the skin is exposed to harmful environmental factors, such as ultraviolet rays, the p53 protein promptly activates its protective mechanism ( Moreover, p53 plays a pivotal role in combating skin aging

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doi: 10.1002/mds.22875 159

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