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Moreover, the mortality of bacterial sepsis mice was increased by metformin administration, which may be because metformin promoted the activation of systemic inflammasomes in mice, as shown by increased serum and liver IL-1 levels (72)

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This decline is partly due to changes in the bodys ability to synthesize the amino acids required for glutathione production and increased oxidative stress with age

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CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

Biological evaluation included in vitro cytotoxicity tests on HepG2, intestinal epithelial cell line (Caco-2), and dopaminergic neurons (Differentiated SH-SY5Y with 0.1% retinoic acid) cell lines, showing low cytotoxicity